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STARD10 Antikörper (AA 1-273)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STARD10 in WB, ELISA, ICC, IF und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7599199

Kurzübersicht für STARD10 Antikörper (AA 1-273) (ABIN7599199)

Target

Alle STARD10 Antikörper anzeigen
STARD10 (StAR-Related Lipid Transfer (START) Domain Containing 10 (STARD10))

Reaktivität

  • 21
  • 15
  • 14
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 21
Kaninchen

Klonalität

  • 21
Polyklonal

Konjugat

  • 11
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser STARD10 Antikörper ist unkonjugiert

Applikation

  • 10
  • 9
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-273

    Verwendungszweck

    Anti-PCTP-L/STARD10 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-PCTP-L/STARD10 Antibody Picoband® (ABIN7599199). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human PCTP-L/STARD10 recombinant protein (Position: M1-E273).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Ito, M., Yamanashi, Y., Toyoda, Y., Izumi-Nakaseko, H., Oda, S., Sugiyama, A., Kuroda, M., Suzuki, H., Takada, T., Adachi-Akahane, S. Disruption of Stard10 gene alters the PPAR-alpha-mediated bile acid homeostasis. Biochim. Biophys. Acta 1831: 459-468, 2013. 2. Olayioye, M. A., Buchholz, M., Schmid, S., Schoffler, P., Hoffmann, P., Pomorski, T. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. J. Biol. Chem. 282: 22492-22498, 2007. 3. Olayioye, M. A., Hoffmann, P., Pomorski, T., Armes, J., Simpson, R. J., Kemp, B. E., Lindeman, G. J., Visvader, J. E. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 64: 3538-3544, 2004.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    STARD10 (StAR-Related Lipid Transfer (START) Domain Containing 10 (STARD10))

    Andere Bezeichnung

    STARD10

    Hintergrund

    Synonyms: Neutrophil defensin 1,Defensin, alpha 1,HNP-1,HP-1,HP1,HP 1-56,Neutrophil defensin 2,HNP-2,HP-2,HP2,DEFA1,DEF1, DEFA2, MRS,DEFA1B,

    Tissue Specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

    Background: StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene. StarD10 is a dual-specificity lipid transfer protein capable of shuttling phosphatidylcholine (PC) and phosphatidylethanolamine (PE) between membranes in vitro, changes in membrane composition of PC and PE occur before the morphological tumorigenic events. Interestingly, STARD10 has been described to be highly expressed in 35-40 % of ERBB2-positive breast cancers. StarD10 was initially discovered based on its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. StarD10 contains a steroidogenic acute regulatory protein (StAR/StarD1)-related lipid transfer (START) domain that is thought to mediate binding of lipids. STARD10 is highly expressed in the liver and has been shown to transfer phosphatidylcholine.

    Molekulargewicht

    37 kDa

    Gen-ID

    10809

    UniProt

    Q9Y365
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