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STARD10 Antikörper (AA 1-273)

STARD10 Reaktivität: Human, Maus, Ratte WB, ELISA, ICC, IF, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7599199
  • Target Alle STARD10 Antikörper anzeigen
    STARD10 (StAR-Related Lipid Transfer (START) Domain Containing 10 (STARD10))
    Bindungsspezifität
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-273
    Reaktivität
    • 19
    • 15
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 19
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser STARD10 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 8
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-PCTP-L/STARD10 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-PCTP-L/STARD10 Antibody Picoband® (ABIN7599199). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human PCTP-L/STARD10 recombinant protein (Position: M1-E273).
    Isotyp
    IgG
    Top Product
    Discover our top product STARD10 Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Ito, M., Yamanashi, Y., Toyoda, Y., Izumi-Nakaseko, H., Oda, S., Sugiyama, A., Kuroda, M., Suzuki, H., Takada, T., Adachi-Akahane, S. Disruption of Stard10 gene alters the PPAR-alpha-mediated bile acid homeostasis. Biochim. Biophys. Acta 1831: 459-468, 2013. 2. Olayioye, M. A., Buchholz, M., Schmid, S., Schoffler, P., Hoffmann, P., Pomorski, T. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. J. Biol. Chem. 282: 22492-22498, 2007. 3. Olayioye, M. A., Hoffmann, P., Pomorski, T., Armes, J., Simpson, R. J., Kemp, B. E., Lindeman, G. J., Visvader, J. E. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 64: 3538-3544, 2004.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    STARD10 (StAR-Related Lipid Transfer (START) Domain Containing 10 (STARD10))
    Andere Bezeichnung
    STARD10 (STARD10 Produkte)
    Hintergrund

    Synonyms: Neutrophil defensin 1,Defensin, alpha 1,HNP-1,HP-1,HP1,HP 1-56,Neutrophil defensin 2,HNP-2,HP-2,HP2,DEFA1,DEF1, DEFA2, MRS,DEFA1B,

    Tissue Specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

    Background: StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene. StarD10 is a dual-specificity lipid transfer protein capable of shuttling phosphatidylcholine (PC) and phosphatidylethanolamine (PE) between membranes in vitro, changes in membrane composition of PC and PE occur before the morphological tumorigenic events. Interestingly, STARD10 has been described to be highly expressed in 35-40 % of ERBB2-positive breast cancers. StarD10 was initially discovered based on its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. StarD10 contains a steroidogenic acute regulatory protein (StAR/StarD1)-related lipid transfer (START) domain that is thought to mediate binding of lipids. STARD10 is highly expressed in the liver and has been shown to transfer phosphatidylcholine.

    Molekulargewicht
    37 kDa
    Gen-ID
    10809
    UniProt
    Q9Y365
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