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ITGB3BP Antikörper (AA 1-177)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ITGB3BP in WB, ELISA, IF und ICC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7599037

Kurzübersicht für ITGB3BP Antikörper (AA 1-177) (ABIN7599037)

Target

Alle ITGB3BP Antikörper anzeigen
ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Reaktivität

  • 23
  • 4
  • 3
  • 1
  • 1
Human

Wirt

  • 21
  • 2
Kaninchen

Klonalität

  • 21
  • 2
Polyklonal

Konjugat

  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ITGB3BP Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-177

    Verwendungszweck

    Anti-Centromere protein R/ITGB3BP Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross reactivity with other proteins.

    Produktmerkmale

    Anti-Centromere protein R/ITGB3BP Antibody Picoband® (ABIN7599037). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Centromere protein R/ITGB3BP recombinant protein (Position: M1-N177). Human ITGB3BP shares 94.4% and 59.8% amino acid (aa) sequence identity with mouse and rat ITGB3BP, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Li, D., Das, S., Yamada, T., Samuels, H. H. The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells. Molec. Cell. Biol. 24: 3838-3848, 2004. 2. Li, D., Desai-Yajnik, V., Lo, E., Schapira, M., Abagyan, R., Samuels, H. H. NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors. Molec. Cell. Biol. 19: 7191-7202, 1999. 3. Li, D., Wang, F., Samuels, H. H. Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation. Molec. Cell. Biol. 21: 8371-8384, 2001.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

    Andere Bezeichnung

    ITGB3BP

    Hintergrund

    Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

    Tissue Specificity: Expressed in all tissues.

    Background: Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

    Molekulargewicht

    20 kDa

    Gen-ID

    23421

    UniProt

    Q13352

    Pathways

    Neurotrophin Signalübertragung
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