C4orf49 Antikörper (AA 1-155)

Produktnummer ABIN7599013

Der Kaninchen Polyklonal anti-C4orf49 Antikörper wird verwendet zum Nachweis von C4orf49 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für C4orf49 Antikörper (AA 1-155) (ABIN7599013)

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C4orf49 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-C4orf49 Antikörper

Bindungsspezifität: AA 1-155

Verwendungszweck: Anti-MGARP Antibody

Homologie: Human C4orf49,MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49,MGARP.

Produktmerkmale: Anti-MGARP Antibody. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu C4orf49

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Andere Bezeichnung: MGARP

Hintergrund:

Background: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

Gene Full Name: mitochondria localized glutamic acid rich protein

Molekulargewicht: 38 kDa

Gen-ID: 84709

UniProt: Q8TDB4