C4orf49 Antikörper (AA 1-155)

Produktnummer ABIN7599013

Produktdetails anti-C4orf49 Antikörper

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Bindungsspezifität: AA 1-155

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C4orf49 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Anti-MGARP Antibody Picoband®

Produktmerkmale: Anti-MGARP Antibody Picoband® (ABIN7599013). Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Jia, L., Liang, T., Yu, X., Ma, C., Zhang, S. MGARP regulates mouse neocortical development via mitochondrial positioning. Molec. Neurobiol. 49: 1293-1308, 2014. 2. Matsumoto, T., Minegishi, K., Ishimoto, H., Tanaka, M., Hennebold, J. D., Teranishi, T., Hattori, Y., Furuya, M., Higuchi, T., Asai, S., Kim, S. H., Miyakoshi, K., Yoshimura, Y. Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis. Endocrinology 150: 3353-3359, 2009. 3. Qi, S., Wang, Y., Zhou, M., Ge, Y., Yan, Y., Wang, J., Zhang, S. S.-M., Zhang, S. A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder. Molec. Biol. Rep. 38: 2869-2877, 2011.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu C4orf49

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Andere Bezeichnung: MGARP (C4orf49 Produkte)

Hintergrund: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

Molekulargewicht: 38 kDa

Gen-ID: 84709