MAFK Antikörper (AA 1-156)

Produktnummer ABIN7596043

Produktdetails anti-MAFK Antikörper

Target: MAFK (Transcription Factor MafK (MAFK))

Bindungsspezifität: AA 1-156

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAFK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Human MafK antibody

Aufreinigung: protein-A affinity chromatography

Immunogen: Recombinant human MAFK (1-156aa) purified from E. coli

Klon: AT2F7

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycero

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Details zu MAFK

Target: MAFK (Transcription Factor MafK (MAFK))

Andere Bezeichnung: MafK (MAFK Produkte)

Hintergrund: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locuscontrol regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by thetranscription factor NFE2 (nuclear factor erythroid-2). NFE2 DNA-binding activity consists of aheterodimer containing an 18-kD Maf protein (MafF, MafG or MafK) and p45. Since Maf homodimers lack aputative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize amongthemselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger)basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerizewith Fos and may act as competitive repressors of the NF-E2 transcription factor. The MafK of Maf proteinsis primarily expressed during development in mesenchymal and hematopoietic cells and neurons.

NCBI Accession: NP_002351