DLG2 Antikörper (AA 1-852) (FL650)

Produktnummer ABIN7595813

Dieses Maus Monoklonal-Antikörper erkennt spezifisch DLG2 in IHC und ICC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für DLG2 Antikörper (AA 1-852) (FL650) (ABIN7595813)

Target: DLG2 (Discs, Large Homolog 2 (DLG2))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DLG2 Antikörper ist konjugiert mit FL650

Applikation: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: N18-30

Produktdetails anti-DLG2 Antikörper (FL650)

Bindungsspezifität: AA 1-852

Verwendungszweck: Anti-Chapsyn-110/PSD-93 Antibody FL650 Conjugate

Spezifität: No off-targets reported for other MAGUK family members PSD-95, SAP97, SAP102 expressed in transfected cells

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Produktmerkmale:

Description: Our Anti-Chapsyn-110/PSD-93 mouse monoclonal primary antibody is produced in-house from hybridoma clone N18/30. It is KO validated, detects human, mouse, rabbit, and rat Chapsyn-110/PSD-93, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Chapsyn-110/PSD-93 mouse monoclonal primary antibody from hybridoma clone N18/30. It is great in IHC, ICC and is purified by Protein A chromatography.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Reinheit: > 90 % specific antibody

Immunogen: Fusion protein amino acids 1-852 of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 12 months

Details zu DLG2

Target: DLG2 (Discs, Large Homolog 2 (DLG2))

Andere Bezeichnung: PSD-93

Hintergrund:

Synonyms: Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

Target Description: PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Gene Name Alternatives: Dlg2 Dlgh2

Molekulargewicht: 110 kDa