SHANK2 Antikörper (AA 84-309) (FL550)

Produktnummer ABIN7595603

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SHANK2 in IHC und ICC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für SHANK2 Antikörper (AA 84-309) (FL550) (ABIN7595603)

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SHANK2 Antikörper ist konjugiert mit FL550

Applikation: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: N23B-6

Produktdetails anti-SHANK2 Antikörper (FL550)

Bindungsspezifität: AA 84-309

Verwendungszweck: Anti-Shank2 Antibody FL550 Conjugate

Spezifität: No off-targets reported for Shank1 or Shank3

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Produktmerkmale:

Description: Our Anti-Shank2 mouse monoclonal primary antibody is produced in-house from hybridoma clone N23B/6. It detects human, mouse, and rat Shank2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Shank2 mouse monoclonal primary antibody from hybridoma clone N23B/6. It is great in IHC, ICC and is purified by Protein A chromatography.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Reinheit: > 90 % specific antibody

Immunogen: Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (accession number Q9QX74) produced recombinantly in E. Coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 12 months

Details zu SHANK2

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Andere Bezeichnung: Shank2

Hintergrund:

Synonyms: SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3)

Target Description: SH3 and multiple ankyrin repeat domains protein 2, or shank 2 is a member of the shank family. Shank 2 binding domains include a SH3 domain, a proline rich domain, and a PDZ domain. Shank 2 is found in kidney, liver tissue, and epithelial cells. In brain, Shank 2 is expressed at the apical cell membrane, cytoplasm, synapse, postsynaptic density, growth cone, and dendritic spine. Some isoforms of shank 2 are expressed during development, while others are expressed in mature tissue. Shank 2 acts as a scaffold protein anchoring and connecting membrane bound receptors, including NMDA and glutamate receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 2 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 2 gene have been associated with autism spectrm disorder and blount disease.

Gene Name Alternatives: Shank2 Cortbp1

Molekulargewicht: 160 kDa