SHANK3 Antikörper (AA 840-857) (FL490)

Produktnummer ABIN7595473

Dieses Anti-SHANK3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SHANK3 in IHC und ICC. Geeignet für Ratte.

Kurzübersicht für SHANK3 Antikörper (AA 840-857) (FL490) (ABIN7595473)

Target: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SHANK3 Antikörper ist konjugiert mit FL490

Applikation: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: N69-46

Produktdetails anti-SHANK3 Antikörper (FL490)

Bindungsspezifität: AA 840-857

Verwendungszweck: Anti-Shank3 Antibody FL490 Conjugate

Spezifität: No off-targets reported for Shank1 or Shank2

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale:

Description: Our Anti-Shank3 mouse monoclonal primary antibody is produced in-house from hybridoma clone N69/46. It detects human, mouse, and rat Shank3, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Shank3 mouse monoclonal primary antibody from hybridoma clone N69/46. It is great in IHC, ICC and is purified by Protein A chromatography.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Reinheit: > 90 % specific antibody

Immunogen: Synthetic peptide amino acids 840-857 (PEKLPGSLRKGIPRTKSV) of rat Shank3 (accession number Q9JLU4)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 12 months

Details zu SHANK3

Target: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Andere Bezeichnung: Shank3

Hintergrund:

Synonyms: SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

Target Description: SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density. Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.

Gene Name Alternatives: Shank3 Prosap2

Molekulargewicht: 190 kDa

Pathways: Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity