CX3CR1 Antikörper (Biotin)

Produktnummer ABIN7595400

Der Ratte Monoklonal Anti-CX3CR1-Antikörper wurde für FACS validiert. Er ist geeignet, CX3CR1 in Proben von Human und Non-Human Primate zu detektieren.

Kurzübersicht für CX3CR1 Antikörper (Biotin) (ABIN7595400)

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Reaktivität: Human, Non-Human Primate

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CX3CR1 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: 2A9-1

Produktdetails anti-CX3CR1 Antikörper (Biotin)

Verwendungszweck: Anti-Hu CX3CR1 Biotin

Spezifität: The rat monoclonal antibody 2A9-1 recognizes an extracellular epitope of CX3CR1, an important regulator of leukocyte trafficking and immune system ballance.

Aufreinigung: Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Immunogen: human CX3CR1 transfectants

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 2-8 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu CX3CR1

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Andere Bezeichnung: CX3CR1

Hintergrund: CX3CR1 (fractalkine receptor) serves as a regulator of leukocyte trafficking. Its ligand CX3CL1 (fractalkine) can serve bots as chemoatractant (soluble) and as adhesive molecule (membrane bound). Binding to the cell surface expressed ligand leads to rapid induction of firm adhesion of CX3CR1-positive cells without requiring selectin-mediated rolling or activation of integrins. This interaction is important for trafficking of cytotoxic effector lymphocytes regardless of their lineage and mode of target cell recognition, through inflamed endothelium. Similarly, it mediates monocyte/macrophage recruitment to inflamed atherosclerotic plaques, as well as in their homing to non-inflamed tissues, where they can differentiate into dendritic cells. CX3CR1 also promotes cell survival, plays a key role in brain microglia, synapse maturation and regulation of inflammatory response in the central nervous system, it acts as a negative regulator of angiogenesis, and serves as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi.

Gen-ID: 1524

UniProt: P49238

Pathways: Cellular Response to Molecule of Bacterial Origin