Periaxin Antikörper (Intracellular)

Produktnummer ABIN7581946

Dieses Meerschweinchen Polyklonal-Antikörper erkennt spezifisch Periaxin in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für Periaxin Antikörper (Intracellular) (ABIN7581946)

Target: Periaxin (PRX)

Reaktivität: Ratte

Wirt: Meerschweinchen

Klonalität: Polyklonal

Konjugat: Dieser Periaxin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Periaxin Antikörper

Bindungsspezifität: AA 155-170, Intracellular

Verwendungszweck: A Guinea Pig Polyclonal Antibody to Periaxin

Sequenz: (C)DVEFSFPKFS RLRR

Spezifität: Intracellular, N-terminus

Homologie: Mouse,human - identical

Produktmerkmale: Guinea pig Anti-Periaxin Antibody (ABIN7581946), formerly ), raised in guinea pig, is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Periaxin from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-Periaxin Antibody (ABIN7043432, ABIN7044712 and ABIN7044713) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation, etc.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DVEFSFPKFSRLRR, corresponding to amino acid residues 155-170 of rat PRX

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200-1:600

Kommentare:

Negative Control: (ABIN7236245)

Blocking Peptide: (ABIN7236245)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu Periaxin

Target: Periaxin (PRX)

Andere Bezeichnung: PRX

Hintergrund: PRX, CMT4F,Periaxin protein is a membrane-associated protein expressed in myelinating Schwann cells. It is required for the stable maintenance and development of a normal myelin sheath in the peripheral nervous system. It is also a member of cytoskeletal complexes in lens fibers where it plays an important role in maturation, packing, and membrane organization of lens fiber cell1,2. The periaxin gene (PRX) encodes two protein isoforms, L-periaxin and S-periaxin generated by alternative mRNA splicing. These proteins contain N-terminal PDZ domains (PSD-95/Discs-large/ZO-1) important for organizing protein-protein interactions.L-periaxin is a component of the dystroglycan-dystrophin-related protein-2 complex (DRP2) linking the Schwann cell cytoskeleton to the extracellular matrix. Its location changes during myelination, at first the protein is localized to the adaxonal plasma membrane and later, in the abaxonal plasma membrane. S-periaxin is distributed in a uniform manner in the cytoplasm and the nucleus of the Schwann cell1-3. Mutations in the Periaxin gene are known to cause autosomal recessive demyelinating in Type 4F Charcot-Marie-Tooth (CMT4F) and Dejerine-Sottas disease3.Periaxin knockout mice develop normally myelinated peripheral nervous system at first but develop a late onset demyelinating peripheral neuropathy1.

Gen-ID: 78960

UniProt: Q63425