NPTX2 Antikörper (Secreted)

Produktnummer ABIN7581924

Dieses Anti-NPTX2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NPTX2 in WB und IHC. Geeignet für Maus.

Kurzübersicht für NPTX2 Antikörper (Secreted) (ABIN7581924)

Target: NPTX2 (Neuronal Pentraxin II (NPTX2))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPTX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-NPTX2 Antikörper

Bindungsspezifität: AA 186-198, Secreted

Verwendungszweck: A Rabbit Polyclonal antibody to Neuronal Pentraxin 2 (NPTX2)

Sequenz: (C)HNETSAHRQK TES

Spezifität: Secreted

Homologie: Human - identical,rat - 12 out of 13 amino acid residues identical

Produktmerkmale: Anti-Neuronal Pentraxin 2 (NPTX2) Antibody (ABIN7581924) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPTX2 from rat, mouse and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)HNETSAHRQKTES, corresponding to amino acid residues 186 - 198 of mouse NPTX2 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu NPTX2

Target: NPTX2 (Neuronal Pentraxin II (NPTX2))

Andere Bezeichnung: NPTX2

Hintergrund: Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP,Neuronal pentraxin 2 (NP2), also known as NPTX2, NP-II, and neuronal activity-regulated pentraxin (Narp), is a calcium-dependent lectin secreted protein member of the pentraxin family involved in synaptic plasticity and excitatory homeostasis.1,2NP2 is part of the neuronal pentraxin family that includes two other members: Neuronal Pentraxin 1 (NP1) and Neuronal Pentraxin Receptor (NPTXR). The pentraxin superfamily members are arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain 2,3.NP2 is widely expressed in the brain, especially in the hippocampus, dentate gyrus, cerebellum, and cerebral cortex regions, as well as in the testis, pancreas, liver, heart, and skeletal muscle.2,3NP2 interacts with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which are crucial for excitatory neurotransmission in the brain. By binding to AMPA receptors, NP2 influences their trafficking and localization at synapses, affecting the strength of excitatory synaptic transmission 2,3.Given its presence in brain regions associated with learning and memory, alterations in NP2 levels or function have been implicated in cognitive processes. Dysregulation of NP2 has been observed in various neurological disorders, suggesting its potential importance in maintaining cognitive function.4-6Abnormalities in NP2 expression have been linked to neurodegenerative disorders, including Alzheimer's disease. Changes in NP2 levels may contribute to synaptic dysfunction and cognitive decline observed in these conditions.4-6

Gen-ID: 53324

UniProt: O70340