GPR108 Antikörper (Extracellular)

Produktnummer ABIN7581883

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch GPR108 in WB, IHC, FACS und LCI. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für GPR108 Antikörper (Extracellular) (ABIN7581883)

Target: GPR108 (G Protein-Coupled Receptor 108 (GPR108))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR108 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-GPR108 Antikörper

Bindungsspezifität: AA 124-137, Extracellular

Verwendungszweck: A Rabbit Polyclonal antibody to GPR108 (extracellular)

Sequenz: (C)KDLQVQVRKY GEQK

Spezifität: Extracellular, N-term.

Homologie: Rat,human - identical

Produktmerkmale: Anti-GPR108 (extracellular) Antibody (ABIN7581883) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize GPR108 from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KDLQVQVRKYGEQK, corresponding to amino acid residues 124 - 137 of mouse GPR108

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu GPR108

Target: GPR108 (G Protein-Coupled Receptor 108 (GPR108))

Andere Bezeichnung: GPR108 

Hintergrund: G-Protein Coupled Receptor 108, Lung Seven Transmembrane Receptor 2, LUSTR2,G protein coupled receptors (GPCR or GPR) comprise a large superfamily of receptors characterized by a seven transmembrane domain structure and an ability to activate intracellular transducer G proteins. Over 800 GPCRs in five main families have been identified in eukaryotes on the basis of genomic sequence analysis1,2. These receptors can be activated by hormones, neurotransmitters, odorants, light, or pheromones. Whereas the endogenous agonist is remains unclear or in dispute2.GPCRs mediated the signaling of extracellular stimuli to intracellular responses via activation of heterotrimeric G proteins and their subsequent interaction with effector proteins. GPCRs have been implicated in a number of physiological functions including development of anxiety, behavior, homeostasis, cognition, appetite, and drug addiction3.The GPCR family contains a diverse group of cell-surface mediators of signal transduction, its size exceeding other cell-surface protein receptors including the tyrosine kinase receptors, guanylyl cyclase receptors and ligand-gated ion channels4.GPR108 (LUSTR2), has a large extracellular domain of an amino-terminal hydrophobic signal peptide sequence, and a carboxy-terminal seven-transmembrane domain5. Previous studies showed that GPR108 is linked to nuclear factor κB (NF-κB) signaling6 and regulates and inflammatory immune response and cancer signaling7.Recently, GPR108 has been identified as a highly conserved cellular entry factor for Adeno-associated virus (AAV), a widely used and clinically approved gene therapy vector8.

Gen-ID: 78308

UniProt: Q91WD0