CNR1 Antikörper (Extracellular)

Produktnummer ABIN7581863

Der Meerschweinchen Polyklonal Anti-CNR1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, CNR1 in Proben von Ratte zu detektieren.

Kurzübersicht für CNR1 Antikörper (Extracellular) (ABIN7581863)

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Reaktivität: Ratte

Wirt: Meerschweinchen

Klonalität: Polyklonal

Konjugat: Dieser CNR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CNR1 Antikörper

Bindungsspezifität: AA 84-99, Extracellular

Verwendungszweck: A Guinea Pig Polyclonal Antibody to Cannabinoid Receptor 1 (extracellular)

Sequenz: NKSLSSFKEN EENIQC

Spezifität: Extracellular, N-terminus

Homologie: Human - identical, mouse - 15,16 amino acid residues identical

Produktmerkmale: Guinea Pig Anti-Cannabinoid Receptor 1 (extracellular) Antibody (ABIN7581863) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CB1R from mouse, rat and human samples. The antigen used to immunize guinea pigs is the same as Anti-Cannabinoid Receptor 1 (extracellular) Antibody (ABIN7043023, ABIN7044155 and ABIN7044156) raised in rabbits. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: NKSLSSFKENEENIQC, corresponding to amino acid residues 84-99 of rat CB1 receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:400

Kommentare:

Negative Control: (ABIN7235028)

Blocking Peptide: (ABIN7235028)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu CNR1

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Andere Bezeichnung: CNR1

Hintergrund: CB1, CB-R, CB1R, CANN6, Brain-type cannabinoid receptor, Central cannabinoid receptor, CNR1,Cannabinoids have been used in Eastern medicine for many years as pain relievers.1 Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 receptor) and cannabinoid receptor 2 (CB2 receptor).2 The cannabinoid receptors can be distinguished by their amino acid sequences, signaling mechanisms, and tissue distributions.2 Both receptors belong to the G-protein coupled receptor (GPCR) superfamily. CB1 was shown to modulate several Ca2+ and K+ ion channels.2,3CB1 is primarily expressed in the central nervous system. However, expression of CB1 is also detected in the peripheral terminals, in non-neuronal peripheral tissues such as uterus, testes, spleen, as well as in cells of the immune system.3,4CB1 is implicated in many cellular functions such as neurotransmitter release, pain relief, cancer, and obesity.5,6 Growth inhibition of tumor cells was demonstrated following mixed CB1/CB2 agonist treatment in both prostate and non-melanoma skin cancers.5,6 Through their interaction with CB1, cannabinoid compounds stimulate appetite for sweets and palatable foods in particular, making CB1 an attractive therapeutic target for the treatment of obesity and eating disorders.7

Gen-ID: 25248

UniProt: P20272

Pathways: Feeding Behaviour