LPHN3 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886548

Der Kaninchen Polyklonal anti-LPHN3 Antikörper wird verwendet zum Nachweis von LPHN3 in Proben von Maus. Er wurde validiert für WB und IHC.

Kurzübersicht für LPHN3 Antikörper (Extracellular, N-Term) (ABIN7886548)

Target: LPHN3 (Latrophilin 3 (LPHN3))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LPHN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-LPHN3 Antikörper

Bindungsspezifität: AA 572-586, Extracellular, N-Term

Verwendungszweck: A Rabbit polyclonal antibody to Latrophilin-3.

Sequenz: (C)REIMWFKTRQ GQVAK

Homologie: Rat - identical,Human- 14,15 identical

Produktmerkmale: Anti-Latrophilin-3 (extracellular) Antibody (ABIN7581821) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Latrophilin-3 from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)REIMWFKTRQGQVAK, corresponding to amino acid residues 572 - 586 of mouse Latrophilin-3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu LPHN3

Target: LPHN3 (Latrophilin 3 (LPHN3))

Andere Bezeichnung: ADGRL3

Hintergrund:

Synonyms: Adhesion G Protein-Coupled Receptor L3, ADGRL3, Calcium-Independent Alpha-Latrotoxin Receptor 3, LPHN3, Lectomedin-3

Description: Latrophilin-3 (LPHN3), also known as ADGRL3, is a member of the adhesion G-protein-coupled receptor (aGPCR) family. This family is characterized by the presence of a GPCR autoproteolysis-inducing (GAIN) domain that facilitates receptor cleavage and activation, along with seven transmembrane domains1,3. LPHN3 is primarily localized to the cell membrane and is prominently expressed in neurons, with high levels observed in brain regions such as the hippocampus and prefrontal cortex1,5. LPHN3 plays critical roles in neuronal development and synapse formation. It mediates its effects through dual mechanisms: coupling with intracellular G-proteins, particularly Gαs and Gα12/13, and recruiting phase-separated postsynaptic protein scaffolds. Activation of LPHN3 is triggered by interactions with its ligands, such as teneurins and FLRTs, which enhance synaptic clustering by promoting scaffold protein condensates. Alternative splicing of Lphn3, studied in mouse models, modulates these pathways, influencing synaptic connectivity and neuronal activity3,4. Biologically, LPHN3 is involved in attention regulation and motor control, with its dysregulation linked to attention deficit hyperactivity disorder (ADHD). Genetic variants in LPHN3 are associated with altered dopaminergic signaling and increased susceptibility to ADHD, as demonstrated in human studies1,2. Furthermore, LPHN3 dysfunction has been implicated in substance use disorders and learning deficits, underscoring its importance in neuropsychiatric and cognitive processes2,5.

Gen-ID: 319387

UniProt: Q80TS3