LPHN3 Antikörper (AA 572-586)

Produktnummer ABIN7581821

Produktdetails anti-LPHN3 Antikörper

Target: LPHN3 (Latrophilin 3 (LPHN3))

Bindungsspezifität: AA 572-586

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LPHN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: A Rabbit Polyclonal Antibody to Latrophilin-3

Sequenz: (C)REIMWFKTRQ GQVAK

Homologie: Rat - identical,Human- 14,15 identical

Produktmerkmale: Anti-Latrophilin-3 (extracellular) Antibody (ABIN7581821) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Latrophilin-3 from mouse, rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)REIMWFKTRQGQVAK, corresponding to amino acid residues 572 - 586 of mouse Latrophilin-3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu LPHN3

Target: LPHN3 (Latrophilin 3 (LPHN3))

Andere Bezeichnung: ADGRL3 (LPHN3 Produkte)

Hintergrund: Adhesion G Protein-Coupled Receptor L3, ADGRL3, Calcium-Independent Alpha-Latrotoxin Receptor 3, LPHN3, Lectomedin-3,Latrophilin-3 (LPHN3), also known as ADGRL3, is a member of the adhesion G-protein-coupled receptor (aGPCR) family. This family is characterized by the presence of a GPCR autoproteolysis-inducing (GAIN) domain that facilitates receptor cleavage and activation, along with seven transmembrane domains1,3. LPHN3 is primarily localized to the cell membrane and is prominently expressed in neurons, with high levels observed in brain regions such as the hippocampus and prefrontal cortex1,5. LPHN3 plays critical roles in neuronal development and synapse formation. It mediates its effects through dual mechanisms: coupling with intracellular G-proteins, particularly Gαs and Gα12/13, and recruiting phase-separated postsynaptic protein scaffolds. Activation of LPHN3 is triggered by interactions with its ligands, such as teneurins and FLRTs, which enhance synaptic clustering by promoting scaffold protein condensates. Alternative splicing of Lphn3, studied in mouse models, modulates these pathways, influencing synaptic connectivity and neuronal activity3,4. Biologically, LPHN3 is involved in attention regulation and motor control, with its dysregulation linked to attention deficit hyperactivity disorder (ADHD). Genetic variants in LPHN3 are associated with altered dopaminergic signaling and increased susceptibility to ADHD, as demonstrated in human studies1,2. Furthermore, LPHN3 dysfunction has been implicated in substance use disorders and learning deficits, underscoring its importance in neuropsychiatric and cognitive processes2,5.

Gen-ID: 319387

UniProt: Q80TS3