Uricase (Uaz) Antikörper

Produktnummer ABIN7581193

Dieser Huhn Polyklonal Antikörper detektiert spezifisch Uricase in ELISA und WB. Es zeigt Reaktivität gegenüber Proben von Aspergillus flavus.

Kurzübersicht für Uricase (Uaz) Antikörper (ABIN7581193)

Target: Uricase (Uaz)

Reaktivität: Aspergillus flavus

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails

Verwendungszweck: Aspergillus flavus uricase Antibody

Produktmerkmale: Chicken Anti-Rasburicase Antibody, Chicken Anti-Aspergillus flavus uricase Antibody

Aufreinigung: Chicken Anti-Aspergillus flavus uricase Antibody has been IgY affinity purified using sepharose resins with immobilized Aspergillus flavus uricase.

Sterilität: Sterile filtered

Immunogen:

Immunogen: Recombinant Aspergillus flavus uricase

Immunogen Type: Recombinant Protein

Anwendungsinformationen

Applikationshinweise: Application Note: Affinity purified chicken polyclonal Anti-Aspergillus flavus uricase antibodies have been tested for use in Western Blot and ELISA. This antibody recognizes structured uricase and will work in western blot when the protein are either denatured or in its native form. Although not tested, this antibody being affinity-purified, polyclonal raised using whole A. flavus uricase immunized to chicken could be useful in detection of uricases from Aspergillus spp that share sequence homologies more than 80 % . Specific conditions for reactivity should be optimized by the end user. Western Blot Dilution: User Optimized ELISA Dilution: User Optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.55 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: None

Konservierungsmittel: Without preservative

Lagerung: 4 °C

Informationen zur Lagerung: Store vial at 2-8° C. Dilute only prior to immediate use.

Haltbarkeit: 6 months

Antigendetails

Target: Uricase (Uaz)

Hintergrund: Aspergillus flavus uricase (Rasburicase) is currently used for the treatment of gout and hyperuricemia occurring in tumor lysis syndrome. Rasburicase, sold under the brand name Elitek in the US and Fasturtec in the EU, is a medication that helps to clear uric acid from the blood. It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. The concentration of uric acid in human serum is 1.5-6.0 mg/dl for women and 2.5-7.0 mg/dl for men. Any increase in the catabolism of purines or decrease in uric acid excretion leads to build up of uric acid in the form of monosodium urate crystals in joints or soft tissues. Moreover, hyperuricemia is also observed tumor lysis syndrome (TLS) and is caused by massive tumor cell lysis followed by catabolism of the nucleic acids to uric acid after chemotherapeutic treatment.

UniProt: Q00511