DLG4 Antikörper (AA 468-560)

Produktnummer ABIN725930

Der Kaninchen Polyklonal Anti-DLG4-Antikörper wurde für WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p) und IHC (fro) validiert. Er ist geeignet, DLG4 in Proben von Ratte, Human, Maus und Affe zu detektieren. Es sind 6+ Publikationen verfügbar.

Kurzübersicht für DLG4 Antikörper (AA 468-560) (ABIN725930)

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reaktivität: Ratte, Human, Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-DLG4 Antikörper

Bindungsspezifität: AA 468-560

Kreuzreaktivität: Human, Affe, Maus, Ratte

Homologie: Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PSD95

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-DLG4 Antikörper (ABIN725930)

Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Luo, Guo, Fan, Lu, Chen, Wang, Shao, Wu, Xu, Lü: "Niche astrocytes promote the survival, proliferation and neuronal differentiation of co-transplanted neural stem cells following ischemic stroke in rats." in: Experimental and therapeutic medicine, Vol. 13, Issue 2, pp. 645-650, (2017) (PubMed).

Li, Wei, Bai, Li, Huang, Lin, Hou, Deng, Zhou, Zhang, Chen: "MicroRNA-574 is involved in cognitive impairment in 5-month-old APP/PS1 mice through regulation of neuritin." in: Brain research, Vol. 1627, pp. 177-88, (2015) (PubMed).

Zhao, Li, Wei, Savage, Zhou, Ma: "Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring." in: Neurobiology of disease, Vol. 68, pp. 145-55, (2014) (PubMed).

Wang, Niu, Zhu, Han, Luo, Zhou, Wang: "Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A." in: Toxicology, Vol. 322, pp. 51-60, (2014) (PubMed).

Zhang, Zheng, Wan, Shao, Liu, Zhang, Zhang: "The potential use of H102 peptide-loaded dual-functional nanoparticles in the treatment of Alzheimer's disease." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 192, pp. 317-24, (2014) (PubMed).

Details zu DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Andere Bezeichnung: PSD95

Hintergrund:

Synonyms: PSD95, SAP9, SAP-9, Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 9, DLG4

Background: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

Gen-ID: 1742

UniProt: P78352

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity