Estrogen Receptor alpha + beta (AA 201-300) Antikörper

Produktnummer ABIN725855

Produktdetails

Target: Estrogen Receptor alpha + beta

Bindungsspezifität: AA 201-300

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Estradiol Receptor alpha + beta

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen

Li, Yang, Yang, Guo, Zhang, Yang, Li: "Antiosteoporotic activity of echinacoside in ovariectomized rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 20, Issue 6, pp. 549-57, (2013) (PubMed).

Antigendetails

Target: Estrogen Receptor alpha + beta

Hintergrund:

Synonyms: Estrogen Receptor alpha/beta, Atherosclerosis, susceptibility to, included, DKFZp686N23123, ER Alpha, ER, ER Beta, ER-alpha, ER-beta, ER[a], ER[b], Era, ERalpha, Erb, Erb2, ERbeta, ESR, ESR BETA, ESR1, ESR1_HUMAN, ESR2, ESRA, ESRB, Estr, Estra, Estradiol Receptor alpha, Estradiol receptor, Estradiol Receptor beta, ESTRB, Estrogen receptor 1 alpha, Estrogen Receptor 1, Estrogen receptor 2 ER beta, Estrogen Receptor 2, Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor, Estrogen receptor beta 4, Estrogen resistance, included, HDL cholesterol, augmented response of, to hormone replacement, included, Myocardial infarction, susceptibility to, included, NR3A1, NR3A2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, OTTHUMP00000017718, OTTHUMP00000017719, RNESTROR.

Background: The estrogen receptor (ER) is a 66 kDa protein that mediates the actions of estrogens in estrogen responsive tissues. It is a member of a large superfamily of nuclear hormone receptors that function as ligand activated transcription factors. The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen receptor, ER beta has recently been described. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti estrogen (e.g. tamoxifen) therapy.

Gen-ID: 2099, 2100