GBP1 Antikörper

Produktnummer ABIN7566425

Produktdetails anti-GBP1 Antikörper

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: anti-GBP1 (human), pAb (IN111)

Produktmerkmale:

Polyclonal antibody. Recognizes endogenous human GBP1. Application: WB. Source: Rabbit. Liquid. In PBS containing 0.05 % sodium azide. Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.

Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.

Aufreinigung: Puified

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human GBP1 protein (aa 200-592).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Details zu GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Andere Bezeichnung: GBP1 (GBP1 Produkte)

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin