Fibronectin Antikörper

Produktnummer ABIN7566419

Der Maus Monoklonal Anti-Fibronectin-Antikörper wurde für WB, IHC, ELISA, ICC und Func validiert. Er ist geeignet, Fibronectin in Proben von Human, Ratte, Maus, Schwein, Rind (Kuh), Huhn, Hund und Affe zu detektieren.

Kurzübersicht für Fibronectin Antikörper (ABIN7566419)

Target: Fibronectin

Reaktivität: Human, Ratte, Maus, Schwein, Rind (Kuh), Huhn, Hund, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Fibronectin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Functional Studies (Func)

Klon: IST-9

Produktdetails anti-Fibronectin Antikörper

Verwendungszweck: anti-Fibronectin (EDA), mAb (blocking) (IST-9) (preservative free)

Produktmerkmale:

Monoclonal Antibody. Isotype: Mouse IgG1.Immunogen: Recombinant Extra Domain A (EDA) region of human cellular fibronectin.. Application: ELISA, FUNC (Blocking), ICC, IHC, WB. Sterile liquid. In PBS. Recombinant Extra Domain A (EDA) region of human cellular fibronectin. Fibronectin is a major component of the extracellular matrix that binds to integrins, cell surfaces and various compounds including collagen, fibrin, heparin, DNA and actin. It occurs in two main forms: plasma and cellular fibronectin. EDA (Extra Domain A)-containing cellular fibronectin (EDA-FN) plays a major role in cell adhesion, growth, migration and differentiation and it is important for processes such as wound healing and embryonic development. It is associated with fibroblast differentiation by increasing alpha-SMA expression, collagen deposition, cell contractility and focal adhesion kinase (FAK) activation. EDA-FN promotes cell spread by interacting with the integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1 and has been shown to promote angiogenesis, lymphangiogenesis and metastasis of colorectal tumors. In transformed or tumor-derived cells the EDA segment is about 10-times higher than in fibronectin from normal fibroblasts and it may therefore be a significant marker for malignancy.

Fibronectin is a major component of the extracellular matrix that binds to integrins, cell surfaces and various compounds including collagen, fibrin, heparin, DNA and actin. It occurs in two main forms: plasma and cellular fibronectin. EDA (Extra Domain A)-containing cellular fibronectin (EDA-FN) plays a major role in cell adhesion, growth, migration and differentiation and it is important for processes such as wound healing and embryonic development. It is associated with fibroblast differentiation by increasing alpha-SMA expression, collagen deposition, cell contractility and focal adhesion kinase (FAK) activation. EDA-FN promotes cell spread by interacting with the integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1 and has been shown to promote angiogenesis, lymphangiogenesis and metastasis of colorectal tumors. In transformed or tumor-derived cells the EDA segment is about 10-times higher than in fibronectin from normal fibroblasts and it may therefore be a significant marker for malignancy.

Aufreinigung: Puified

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant Extra Domain A (EDA) region of human cellular fibronectin.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Sterile liquid. In PBS.

Konservierungsmittel: Without preservative

Handhabung: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Details zu Fibronectin

Target: Fibronectin