PP2A alpha/beta Antikörper (AA 205-309)

Produktnummer ABIN723875

Der Kaninchen Polyklonal Anti-PP2A alpha/beta-Antikörper wurde für WB, IF (cc), IF (p), ELISA, FACS, IHC (p) und IHC (fro) validiert. Er ist geeignet, PP2A alpha/beta in Proben von Human und Maus zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PP2A alpha/beta Antikörper (AA 205-309) (ABIN723875)

Target: PP2A alpha/beta (PP2A A/B)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PP2A alpha/beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PP2A alpha/beta Antikörper

Bindungsspezifität: AA 205-309

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PP-2A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-PP2A alpha/beta Antikörper (ABIN723875)

Lin, Bo, Tan, Sun, Song, Zhao, Ma, Li, Zheng, Xu: "Feasibility of ?-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on ?-Amyloid Hypothesis." in: PLoS ONE, Vol. 9, Issue 11, pp. e112052, (2014) (PubMed).

Zhao, Di, Liu, Liu, Lai, Lü: "Involvement of GSK3 and PP2A in ginsenoside Rb1's attenuation of aluminum-induced tau hyperphosphorylation." in: Behavioural brain research, Vol. 241, pp. 228-34, (2013) (PubMed).

Details zu PP2A alpha/beta

Target: PP2A alpha/beta (PP2A A/B)

Andere Bezeichnung: PP2A alpha / beta

Hintergrund:

Synonyms: RP-C, PP2Ac, PP2CA, PP2Calpha, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, Replication protein C, PPP2CA

Background: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV4 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

Gen-ID: 5515

UniProt: P67775