Rekombinanter NCR1 Antikörper

Produktnummer ABIN7543464

Der Kaninchen Chimeric anti-NCR1 Antikörper wird verwendet zum Nachweis von NCR1 in Proben von Maus. Er wurde validiert für FACS und Act.

Kurzübersicht für Rekombinanter NCR1 Antikörper (ABIN7543464)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser NCR1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Activation (Act)

Klon: 29A1-4

Produktdetails anti-NCR1 Antikörper

Verwendungszweck: Anti-Nkp46 [29A1.4], Rabbit IgG, kappa

Spezifität:

This antibody is specific for mouse NKp46-Fc.

Application Notes original Clone: The original format of this antibody was used in an FC analysis to detect NKp46 expression on NK cells and to activate NK in an NK cell stimulation assay (Walzer et al., 2007, PMID: 17360655). This antibody was used as a component of bispecific NKCEs (Natural Killer Cell Engagers) to redirect the cytotoxic activity of NK cells towards human CD20-expressing tumor cells in a transplantable xenogeneic in vivo solid tumor model (Gauthier et al., 2019, PMID: 31155232).

Produktmerkmale: This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing rats with mouse NKp46-Fc recombinant protein.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

OriginalSpeciesName: Rat

OriginalFormat: IgG2a

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Andere Bezeichnung: Nkp46

Hintergrund: CD335, NK-p46, NKp46, mNKp46, mAR-1, Activating receptor 1, Lymphocyte antigen 94, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1

UniProt: Q8C567

Pathways: Regulation of Leukocyte Mediated Immunity