Rekombinanter Ferritin Antikörper

Produktnummer ABIN7543451

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch Ferritin in IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter Ferritin Antikörper (ABIN7543451)

Target: Ferritin (FE)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Ferritin Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Klon: AMB8LK

Produktdetails anti-Ferritin Antikörper

Verwendungszweck: Anti-Ferritin [AMB8LK], Rabbit IgG, kappa

Spezifität: This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody was capable of immunoprecipitating ferritin (PMID: 6817879). The original antibody binds human ferritin with a binding affinity of Kd= 5.1nM (EP2193147). The thiolated version of this antibody was conjugated to maleimide-activated polylactide nanoparticles (NPs) to generate immunonanoparticles, which may carry drugs to desired overexpressing antigen cells potentially leading to improved drug therapy and reduced systemic adverse effects (PMID: 19835957). Preclinical studies showed that the immunoconjugate with 90Y has 98 % stability over 7 days. A very good pancreatic adenocarcinoma tumor targeting was observed especially with the Bz-DTPA-AMB8LK (PMID: 17383579)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu Ferritin

Target: Ferritin (FE)

Andere Bezeichnung: Ferritin

Hintergrund: FTMT, FTL, FTH1, Ferritin mitochondrial, B8

UniProt: Q8N4E7

Pathways: Transition Metal Ion Homeostasis