Rekombinanter Dystroglycan Antikörper

Produktnummer ABIN7543384

Dieses Anti-Dystroglycan-Antikörper ist ein Kaninchen Chimeric-Antikörper zur Detektion von Dystroglycan in ELISA und FACS. Geeignet für Human.

Kurzübersicht für Rekombinanter Dystroglycan Antikörper (ABIN7543384)

Target: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser Dystroglycan Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Klon: P38G1

Produktdetails anti-Dystroglycan Antikörper

Verwendungszweck: Anti-Beta Dystroglycan [P38G1], Rabbit IgG, kappa

Spezifität: This antibody recognizes human and mouse beta dystroglycan (β-DAG). Beta-dystroglycan is a transmembrane protein that plays an important role in connecting the extracellular matrix to the cytoskeleton. It plays an important role in linking dystrophin to the laminin-binding alpha-dystroglycan. It acts as a cell adhesion receptor in both muscle and non-muscle tissues. It also functions in cell adhesion-mediated signaling and implicated in cell polarity.

Kreuzreaktivität: Maus

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing BALB/c mice with a mixture of transfected HEK 293 cells expressing human and mouse beta-DAG.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: The binding specificity of this antibody to human and mouse beta dystroglycan expressed on the surface of CHO cells was confirmed using ELISA and flow cytometry. The binding affinity of the original IgG antibody to human beta dystroglycan was determined to be 941 pM. This antibody was used in combination with anti-Laminin antibody PL60B3 for the generation of a bispecific antibody (CN113651891).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu Dystroglycan

Target: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Andere Bezeichnung: Beta Dystroglycan

Hintergrund: Dystroglycan 1, Dag1, Beta-DG, β-DAG, BETA DAG, Dystroglycan, Dystrophin-associated glycoprotein 1, B-Dystroglycan, B Dystroglycan, Beta-dystroglycan, β dystroglycan, β-dystroglycan

UniProt: Q14118, Q62165

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus