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Rekombinanter T Cell Receptor Antikörper

Reaktivität: Human FACS, IP, IF, BR Wirt: Maus Monoclonal BMA031 unconjugated Recombinant Antibody
Produktnummer ABIN7543146
  • Target
    T Cell Receptor
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 7
    • 4
    Human
    Wirt
    • 4
    • 3
    • 2
    • 2
    Maus
    Klonalität
    • 8
    • 3
    Monoklonal
    Konjugat
    • 10
    • 1
    Unkonjugiert
    Applikation
    • 11
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Blocking Reagent (BR)
    Verwendungszweck
    Anti-TCR [BMA031], Mouse IgG2b, kappa
    Spezifität
    This antibody reacts with surface receptors on all alpha-beta TCR bearing cells, but does not react with receptors on gamma-delta T cells. TCR-αβ is expressed by the majority of mature CD3+ T cells.
    Produktmerkmale

    Original Species of Ab: Mouse

    Original Format of Ab: IgG2b

    Aufreinigung
    Protein A affinity purified
    Immunogen
    The original antibody was generated by immunizing mice with human perihperal blood T-lymphocytes.
    Klon
    BMA031
    Isotyp
    IgG2b kappa
  • Applikationshinweise
    This antibody is recomended for detection of viable human αβ+ TCR lymphocyte. It is highly effective in modulating immune reactions and is capable of activating human T lymphocytes in vito (PMID: 3092794). Double immunofluorescence staining was used to ascertain that this antibody does not cross react with γδ+ TCR cells. FACS analysis confirmed that BMA031 did not react with γδ+ TCR cells. BMA031 successfully precipitates TCR αβ/CDR complex (PMID: 1704361). BMA031 in conjugation with triple drug induction treatment in kidney-transplanted patients showed no side effects and reduction in graft rejections (PMID: 2978369). A clinical phase II trial administered 50 mg of murine anti-human alpha/beta-TCR mAb (BMA 031) intravenously on the day of, as well as 2 and 4 days after, cadaveric donor renal transplantation in combination with a CsA/prednisone regimen. After a minimum of 30 months follow-up, the actual allograft survival rate was 87 % in the BMA-treated group compared with 68 % in the control cohort (PMID: 8009591).Humanized version of this antibody BMA 031-EUCIV3 is found to have 2.5 times less affinity than its murine parent, however the ability to cause antibody dependent cell-mediated cytolysis was significantly enhanced (PMID: 1836485).
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    T Cell Receptor
    Andere Bezeichnung
    TCR
    Hintergrund
    Human α/β T Cell Receptor (TCR)
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