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Rekombinanter T Cell Receptor Antikörper

Reaktivität: Human FACS, IP, IF, BR Wirt: Kaninchen Chimeric BMA031 unconjugated Recombinant Antibody
Produktnummer ABIN7543145
  • Target
    T Cell Receptor
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 7
    • 4
    Human
    Wirt
    • 4
    • 3
    • 2
    • 2
    Kaninchen
    Klonalität
    • 9
    • 2
    Chimeric
    Konjugat
    • 10
    • 1
    Unkonjugiert
    Applikation
    • 11
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Blocking Reagent (BR)
    Verwendungszweck
    Anti-TCR [BMA031], Rabbit IgG, kappa
    Spezifität
    This antibody reacts with surface receptors on all alpha-beta TCR bearing cells, but does not react with receptors on gamma-delta T cells. TCR-αβ is expressed by the majority of mature CD3+ T cells.
    Produktmerkmale

    Original Species of Ab: Mouse

    Original Format of Ab: IgG2b

    Aufreinigung
    Protein A affinity purified
    Immunogen
    The original antibody was generated by immunizing mice with human perihperal blood T-lymphocytes.
    Klon
    BMA031
    Isotyp
    IgG kappa
  • Applikationshinweise
    This antibody is recomended for detection of viable human αβ+ TCR lymphocyte. It is highly effective in modulating immune reactions and is capable of activating human T lymphocytes in vito (PMID: 3092794). Double immunofluorescence staining was used to ascertain that this antibody does not cross react with γδ+ TCR cells. FACS analysis confirmed that BMA031 did not react with γδ+ TCR cells. BMA031 successfully precipitates TCR αβ/CDR complex (PMID: 1704361). BMA031 in conjugation with triple drug induction treatment in kidney-transplanted patients showed no side effects and reduction in graft rejections (PMID: 2978369). A clinical phase II trial administered 50 mg of murine anti-human alpha/beta-TCR mAb (BMA 031) intravenously on the day of, as well as 2 and 4 days after, cadaveric donor renal transplantation in combination with a CsA/prednisone regimen. After a minimum of 30 months follow-up, the actual allograft survival rate was 87 % in the BMA-treated group compared with 68 % in the control cohort (PMID: 8009591).Humanized version of this antibody BMA 031-EUCIV3 is found to have 2.5 times less affinity than its murine parent, however the ability to cause antibody dependent cell-mediated cytolysis was significantly enhanced (PMID: 1836485).
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    T Cell Receptor
    Andere Bezeichnung
    TCR
    Hintergrund
    Human α/β T Cell Receptor (TCR)
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