Rekombinanter GDF8 (Lintuzumab Biosimilar) Antikörper

Produktnummer ABIN7543068

Der Human Monoklonal anti-GDF8 (Lintuzumab Biosimilar) Antikörper wird verwendet zum Nachweis von GDF8 (Lintuzumab Biosimilar) in Proben von Human. Er wurde validiert für Func.

Kurzübersicht für Rekombinanter GDF8 (Lintuzumab Biosimilar) Antikörper (ABIN7543068)

Target: GDF8 (Lintuzumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Functional Studies (Func)

Klon: SGN-33

Produktdetails

Verwendungszweck: Anti-CD33 [SGN-33 (Lintuzumab)], Human IgG1, kappa

Spezifität: This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: This humanized antibody was prepared by combining the CDR regions of the murine anti-CD33 M195 with human framework and constant regions.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).

Kommentare:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Antigendetails

Target: GDF8 (Lintuzumab Biosimilar)

Andere Bezeichnung: CD33 (Lintuzumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: Sialic acid-binding Ig-like lectin 3, gp67, HuM195

UniProt: P20138