Rekombinanter RSV (Felvizumab Biosimilar) Antikörper

Produktnummer ABIN7543067

Dieses Maus Chimeric-Antikörper erkennt spezifisch RSV (Felvizumab Biosimilar) in ELISA und Func. Er zeigt eine Reaktivität gegenüber Respiratory Syncytial Virus (RSV).

Kurzübersicht für Rekombinanter RSV (Felvizumab Biosimilar) Antikörper (ABIN7543067)

Target: RSV (Felvizumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Respiratory Syncytial Virus (RSV)

Wirt: Maus

Klonalität: Chimeric

Konjugat: Dieser RSV (Felvizumab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA, Functional Studies (Func)

Klon: RSHZ19

Produktdetails anti-RSV (Felvizumab Biosimilar) Antikörper

Verwendungszweck: Anti-RSV [RSHZ19 (Felvizumab)], Mouse IgG2a, kappa

Spezifität: This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).

Kommentare:

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu RSV (Felvizumab Biosimilar)

Target: RSV (Felvizumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: SB 209763, respiratory syncytial virus