Rekombinanter TNF alpha (Adalimumab Biosimilar) Antikörper

Produktnummer ABIN7543059

Der Maus Chimeric Anti-TNF alpha (Adalimumab Biosimilar)-Antikörper wurde für ELISA, BR, IF und IHC validiert. Er ist geeignet, TNF alpha (Adalimumab Biosimilar) in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter TNF alpha (Adalimumab Biosimilar) Antikörper (ABIN7543059)

Target: TNF alpha (Adalimumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Chimeric

Konjugat: Dieser TNF alpha (Adalimumab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon: D2E7

Produktdetails anti-TNF alpha (Adalimumab Biosimilar) Antikörper

Verwendungszweck: Anti-TNF alpha [D2E7 (Adalimumab)], Mouse IgG2a, kappa

Spezifität: Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).

Kreuzreaktivität: Maus

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).

Kommentare:

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu TNF alpha (Adalimumab Biosimilar)

Target: TNF alpha (Adalimumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: Tumor necrosis factor alpha

UniProt: P01375