EBV LMP1 Antikörper

Produktnummer ABIN7540659

Hersteller Produkt- Nr.: mob194-01

Produktdetails anti-EBV LMP1 Antikörper

Target: EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))

Reaktivität: Epstein-Barr Virus (EBV)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EBV LMP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Hersteller Produkt- Nr.: mob194-01

Hersteller: Rockland

Verwendungszweck: LMP-1 (Epstein-Barr Virus) Monoclonal Antibody

Kreuzreaktivität (Details): This antibody is specific to 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV.

Aufreinigung: The antibody was clarified from tissue culture supernatant.

Immunogen: Anti-LMP-1 (Epstein-Barr Virus) antibody was produced in mice by repeated immunizations with recombinant fusion protein containing sequences of bacterial beta-galactosidase and EBV encoded latent membrane protein.

Klon: CS1-CS2-CS3-CS4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:50-1:100

Kommentare:

Anti-LMP-1 (Epstein-Barr Virus) (MOUSE) Monoclonal Antibody was tested in IHC-P with positive control infected lymphoblastoma, Hodgkin's lymphoma tissues. Cellular Localization: Cytoplasmic. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. This antibody is suitable for use until the expiration date when stored at 2-8°C. Do not use product after the expiration date printed on vial. If reagents are stored under conditions other than those specified here, they must be verified by the user. Diluted reagents should be used promptly. Unused portions of antibody preparation should be discarded after one day. The presence of precipitate or an unusual odor indicates that the antibody is deteriorating and should not be used.

Details zu EBV LMP1

Target: EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))

Andere Bezeichnung: EBV LMP-1 (EBV LMP1 Produkte)

Substanzklasse: Viral Protein

Hintergrund: Epstein-Barr Virus, EBV, Latent Membrane Protein 1, Human herpesvirus 4, HHV-4,Latent membrane protein 1 acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. It functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, LMP1 induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.