CDK5R1 Antikörper (N-Term)

Produktnummer ABIN7540597

Hersteller Produkt- Nr.: 600-401-me9

Dieses Anti-CDK5R1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CDK5R1 in WB, ELISA und IHC. Geeignet für Maus.

Kurzübersicht für CDK5R1 Antikörper (N-Term) (ABIN7540597)

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK5R1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CDK5R1 Antikörper

Bindungsspezifität: N-Term

Hersteller Produkt- Nr.: 600-401-me9

Hersteller: Rockland

Verwendungszweck: p35 Antibody

Kreuzreaktivität (Details): This affinity purified antibody is directed against mouse p35/Cdk5.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Sterilität: Sterile filtered

Immunogen: Anti-p35/Cdk5 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a near N-terminal portion of mouse p35/Cdk5 conjugated to Keyhole Limpet Hemocyanin (KLH).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:10,000 - 1:50,000

Immunohistochemistry_Dilution: 1:100

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-p35/Cdk5 Antibody has been tested in ELISA, WB, and IHC.  Expect bands ~34 kDa in western blot using appropriate tissues and lysates.  Positive control used: mouse brain lysate in WB and IHC. This antibody is suitable in IF.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu CDK5R1

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Andere Bezeichnung: Cdk5r1

Hintergrund: Rabbit Anti-Cyclin Dependent Kinase 5 Regulatory Subunit 1 Antibody, Rabbit Anti-Cyclin-dependent kinase 5 activator 1 Antibody, Rabbit Anti-p35 Antibody, TPKII Regulatory Subunit, CDK5 Activator 1, CDK5R, NCK5A, Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (P35), Cyclin-Dependent Kinase 5 Regulatory Subunit 1, Cyclin-Dependent Kinase 5 Activator 1, Tau Protein Kinase II 23 kDa Subunit, Regulatory Partner For CDK5 Kinase, Neuronal CDK5 Activator, P35nck5a, CDK5P35, P23, P25, P35 ,p35, is a neuron specific activator of CDK5. Also known as Cdk5r1 (Cyclin-dependent kinase 5 activator 1), the complex p35/CDK5 is required for neurite outgrowth and cortical lamination. It is involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Diseases associated with CDK5R1 include Alzheimer Disease and Non-Syndromic Intellectual Disability. Anti-p35/Cdk5 Antibody is useful for researchers interested in Alzheimer researcher, protein kinase binding, Neuroscience Research, and Cancer Research.

Gen-ID: 12569

NCBI Accession: NP_034001

UniProt: P61809

Pathways: Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity