Rekombinanter CD20 Antikörper

Produktnummer ABIN7540551

Hersteller Produkt- Nr.: 400-001-mt2

Der Humanized Monoklonal anti-CD20 Antikörper wird verwendet zum Nachweis von CD20 in Proben von Human. Er wurde validiert für FACS, WB und ELISA.

Kurzübersicht für Rekombinanter CD20 Antikörper (ABIN7540551)

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Antikörpertyp: Recombinant Antibody

Fragment: Fab fragment

Reaktivität: Human

Wirt: Humanized

Klonalität: Monoklonal

Konjugat: Dieser CD20 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), ELISA

Klon: Abz522

Produktdetails anti-CD20 Antikörper

Hersteller Produkt- Nr.: 400-001-mt2

Hersteller: Rockland

Verwendungszweck: Recombinant Anti-CD20 Fab Antibody

Aufreinigung: Humanized Recombinant CD20 Fab fragment was expressed in E.coli cells

Sterilität: Sterile filtered

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: User Optimized

Flow_Cytometry_Dilution: User Optimized

Western_Blot_Dilution: User Optimized

Kommentare:

Recombinant Anti-CD20 Fab fragment Antibody has been tested for use in Flow Cytometry. This antibody recognizes structured CD20 and will work in western blot when the protein has not been denatured with DTT or bMe. Although not tested, this antibody could be useful in in IHC and in in-vivo and other cellular assays. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 30 % Glycerol

Preservative: None

Konservierungsmittel: Without preservative

Lagerung: 4 °C

Informationen zur Lagerung: Store vial at 2-8° C. Dilute only prior to immediate use.

Haltbarkeit: 6 months

Details zu CD20

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Andere Bezeichnung: MS4A1

Hintergrund: Membrane Spanning 4-Domains A1, Recombinant Monoclonal CD20, RabMab CD20, Bp35, Membrane-Spanning 4-Domains, Subfamily A, Member 1, Leukocyte Surface Antigen Leu-16, B-Lymphocyte Antigen CD20, CD20 Antigen, MS4A2, CD20, B1, Membrane-Spanning 4-Domains Subfamily A Member 1, B-Lymphocyte Cell-Surface Antigen B1, B-Lymphocyte Surface Antigen B1, CD20 Receptor, LEU-16, CVID5, MS4A1, S7, Rituximab, Rituxan,CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 Molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. Anti-CD20 antibody, Rituximab, sold under the brand name Rituxan, is a medication used to treat certain autoimmune diseases and types of cancer. It is used for non-Hodgkin lymphoma, chronic lymphocytic leukemia (in non-geriatric patients), rheumatoid arthritis, granulomatosis with polyangiitis, idiopathic thrombocytopenic purpura, pemphigus vulgaris, myasthenia gravis and Epstein-Barr virus-positive mucocutaneous ulcers. Biosimilars of Rituxan include Blitzima, Riabni, Ritemvia, Rituenza (F.K.A. Tuxella), Rixathon, Ruxience, and Truxima. This antibody is made from a Rituximab Fab fragment making it specific, efficient, and effective. Recombinant Anti-CD20 Fab fragment Antibody is useful for researchers interested in autoimmune disease and cancer research.

Gen-ID: 931

NCBI Accession: NP_068769

UniProt: P11836