TREM1 Antikörper (APC)

Produktnummer ABIN7540440

Der Maus Monoklonal Anti-TREM1-Antikörper wurde für FACS validiert. Er ist geeignet, TREM1 in Proben von Human zu detektieren.

Kurzübersicht für TREM1 Antikörper (APC) (ABIN7540440)

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TREM1 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: 6B1

Produktdetails anti-TREM1 Antikörper (APC)

Verwendungszweck: Anti-Hu CD354 APC

Spezifität: The mouse monoclonal antibody 6B1 (also known as 6B1.1G12) recognizes an extracellular epitope of human CD354 (TREM-1), a transmembrane glycoprotein, serving as an important innate immunity receptor.

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: recombinant human CD354 fused with IgG

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu TREM1

Target: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Andere Bezeichnung: CD354

Hintergrund:

NCBI Full Gene Name: triggering receptor expressed on myeloid cells 1

Description: CD354 (TREM-1), a cell surface glycoprotein expressed mainly on monocytes, macrophages, and neutrophils, but also on e.g. endothelial cells or bronchial epithelium, plays an important role in innate immune responses. Upon triggering by its ligands (mainly bacterial and fungal components, but also some viruses, such as Marburg or Ebola virus), it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines. CD354 is strongly present in infectious inflammatory lesions (e.g. in folliculitis or impetigo), but not so much in non-infectious inflammatory lesions, (e.g. vasculitis or psoriasis). However, under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions, e.g. in rheumatoid arthritis. Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients, as well as for prediction of their survival.

Other names: TREM-1

Gene name: TREM1

Gen-ID: 54210

UniProt: Q9NP99