MCAM Antikörper (APC)

Produktnummer ABIN7540418

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MCAM in FACS. Er zeigt eine Reaktivität gegenüber Human, Maus, Kaninchen und Hund.

Kurzübersicht für MCAM Antikörper (APC) (ABIN7540418)

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reaktivität: Human, Maus, Kaninchen, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MCAM Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: P1H12

Produktdetails anti-MCAM Antikörper (APC)

Verwendungszweck: Anti-Hu CD146 APC

Spezifität: The mouse monoclonal antibody P1H12 recognizes an extracellular epitope of CD146, a 118 kDa transmembrane glycoprotein expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, melanoma cells, activated T cells and activated keratinocytes.

Keine Kreuzreaktivität: Ratte

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: cultured human umbilical cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu MCAM

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Andere Bezeichnung: CD146

Hintergrund:

NCBI Full Gene Name: melanoma cell adhesion molecule

Description: CD146, also known as MCAM (melanoma cell adhesion molecule) or MUC18, is a heavily glycosylated transmembrane glycoprotein with more than 50 % of the mass from carbohydrates. It is expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, activated T cells and activated keratinocytes, and on some cancer cells, especially melanoma. The presence of CD146 on circulating blood cells has been confined to the activated T cells rather than circulating endothelial cells. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration.

Other names: MelCAM, MCAM, MUC18

Gene name: MCAM

Gen-ID: 4162

UniProt: P43121