Thrombomodulin Antikörper (APC)

Produktnummer ABIN7540415

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Thrombomodulin in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Thrombomodulin Antikörper (APC) (ABIN7540415)

Target: Thrombomodulin (THBD)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thrombomodulin Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: M80

Produktdetails anti-Thrombomodulin Antikörper (APC)

Verwendungszweck: Anti-Hu CD141 APC

Spezifität: The mouse monoclonal antibody M80 recognizes an extracellular epitope of CD141, a 75 kDa transmembrane glycoprotein expressed mainly on macrophages, monocytes, platelets and endothelial cells.

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: MV4-11 cell line

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Details zu Thrombomodulin

Target: Thrombomodulin (THBD)

Andere Bezeichnung: CD141

Hintergrund:

NCBI Full Gene Name: thrombomodulin

Description: CD141, also known as thrombomodulin or fetomodulin, is a single chain type I transmembrane glycoprotein serving as a receptor for thrombin and as an important cofactor in the protein C anticoagulant system, but it is also involved in embryonic and atherosclerotic plaque development. CD141 is expressed mainly on macrophages, monocytes, a subpopulation of myeloid dendritic cells, on platelets and endothelial cells, but also e.g. on keratinocytes (epithelium). After binding to thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. Mutations in the CD141 gene can cause a thromboembolic disease known as inherited thrombophilia.

Other names: Thrombomodulin, fetomodulin, THBD, THRM, THPH12, TM

Gene name: THBD

Gen-ID: 7056

UniProt: P07204