beta Arrestin 1 Antikörper (AA 89-268)

Produktnummer ABIN7539841

Der Maus Monoklonal Anti-beta Arrestin 1-Antikörper wurde für ELISA validiert. Er ist geeignet, beta Arrestin 1 in Proben von Human zu detektieren.

Kurzübersicht für beta Arrestin 1 Antikörper (AA 89-268) (ABIN7539841)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Arrestin 1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 4E11B1

Produktdetails anti-beta Arrestin 1 Antikörper

Bindungsspezifität: AA 89-268

Verwendungszweck: ARRB1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human ARRB1 (AA: 89-268) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Andere Bezeichnung: ARRB1

Hintergrund: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Molekulargewicht: 47 kDa

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction