Der Human Chimeric anti-EGFR (Margetuximab Biosimilar) Antikörper wird verwendet zum Nachweis von EGFR (Margetuximab Biosimilar) in Proben von Human. Er wurde validiert für ELISA und WB.
Research Grade
Reaktivität: Human
Wirt: Chimeric
Chimeric
unconjugated
Recombinant Antibody
Beschränkungen
Nur für Forschungszwecke einsetzbar
Buffer
PBS buffer PH7.5
Lagerung
-80 °C
Informationen zur Lagerung
store at -80°C
Target
EGFR (Margetuximab Biosimilar)
Substanzklasse
Biosimilar
Hintergrund
Margetuximab is an Fc-engineered human/mouse chimeric anti-HER2 monoclonal antibody of isotype IgG1 kappa . Margetuximab targets the same epitope on the HER2 extracellular domain and hass the same activity as trastuzumab. However, margetuximab has a higher affinity for both CD16A variants and a weaker one to the inhibitory CD32B Fc receptor, thereby resulting in more efficient antibody-dependent cell-mediated cytotoxicity (ADCC) and higher efficacy compared to trastuzumab.