Rekombinanter EGFR (Margetuximab Biosimilar) Antikörper
Kurzübersicht für Rekombinanter EGFR (Margetuximab Biosimilar) Antikörper (ABIN7538064)
Target
Antikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Güteklasse
-
-
Expressionssystem
- Mammalian cells
-
Verwendungszweck
- Margetuximab Biosimilar - Anti-ERBB2, EGFR2, CD340 mAb - Research Grade
-
Produktmerkmale
- Antibody Type: IgG1-kappa
-
Aufreinigung
- Recombinant antibody expressed in mammalien cells and purified.
-
Reinheit
- > 85%
-
Isotyp
- IgG1 kappa
-
-
-
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Buffer
- PBS buffer PH7.5
-
Lagerung
- -80 °C
-
Informationen zur Lagerung
- store at -80°C
-
-
- EGFR (Margetuximab Biosimilar)
-
Substanzklasse
- Biosimilar
-
Hintergrund
- Margetuximab is an Fc-engineered human/mouse chimeric anti-HER2 monoclonal antibody of isotype IgG1 kappa . Margetuximab targets the same epitope on the HER2 extracellular domain and hass the same activity as trastuzumab. However, margetuximab has a higher affinity for both CD16A variants and a weaker one to the inhibitory CD32B Fc receptor, thereby resulting in more efficient antibody-dependent cell-mediated cytotoxicity (ADCC) and higher efficacy compared to trastuzumab.
-
CAS-Nummer
- 1350624-75-7
Target
-