Rekombinanter OC126 (Abagovomab Biosimilar) Antikörper

Produktnummer ABIN7538052

Der Human Monoklonal anti-OC126 (Abagovomab Biosimilar) Antikörper wird verwendet zum Nachweis von OC126 (Abagovomab Biosimilar) in Proben von Maus. Er wurde validiert für ELISA und WB.

Kurzübersicht für Rekombinanter OC126 (Abagovomab Biosimilar) Antikörper (ABIN7538052)

Target: OC126 (Abagovomab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser OC126 (Abagovomab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Güteklasse: Research Grade

Produktdetails anti-OC126 (Abagovomab Biosimilar) Antikörper

Expressionssystem: Mammalian cells

Verwendungszweck: Abagovomab Biosimilar - Anti-idiotope of anti-Mus musculus monoclonal antibody OC126 mAb - Research Grade

Produktmerkmale: Antibody Type: idiotypic IgG1-kappa

Aufreinigung: Recombinant antibody expressed in mammalien cells and purified.

Reinheit: > 85%

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS buffer PH7.5

Lagerung: -80 °C

Informationen zur Lagerung: store at -80°C

Details zu OC126 (Abagovomab Biosimilar)

Target: OC126 (Abagovomab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: Abagovomab is a murine monoclonal anti-idiotypic antibody (MW: 165-175 kDa), produced by a mouse hybridoma and generated against OC125, which serves to functionally imitate the human cancer antigen 125 (CA-125). Abagovomab has been developed by the pharmaceutical company Menarini for the treatment of ovarian cancer. It (ab2) shows high affinity for the paratope of ab1, and binding of ab2 to Ab1 is almost completely inhibited (93%) by the nominal antigen. The administration of F(ab')2 fragments of abagovomab to rats produces anti-CA-125 immunity with the production of IgG and IgM anti-anti-idiotypic antibodies (ab3) that bind both to abagovomab and CA-125. Non-MHC restricted cell-mediated cytotoxicity for NIH OVCAR3 cell lines is also demonstrated.

CAS-Nummer: 792921-10-9