FOXP3 Antikörper (APC)

Produktnummer ABIN7537020

Der Ratte Monoklonal Anti-FOXP3-Antikörper wurde für ICFC validiert. Er ist geeignet, FOXP3 in Proben von Maus zu detektieren.

Kurzübersicht für FOXP3 Antikörper (APC) (ABIN7537020)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist konjugiert mit APC

Applikation: Intracellular Flow Cytometry (ICFC)

Klon: FJK-16s

Produktdetails anti-FOXP3 Antikörper (APC)

Verwendungszweck: APC Anti-Mouse/Rat Foxp3 Antibody [FJK-16s]

Aufreinigung: Purified

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10⁶ cells in 100 μL volume].

Kommentare:

Matching Isotype Control: (ABIN7469841)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Lagerung: 4 °C

Informationen zur Lagerung: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Haltbarkeit: 12 months

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: Foxp3

Hintergrund: Foxp3,Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2,FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4⁺/CD25^- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.

Gen-ID: 20371

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation