Arginine-Gingipain B (RgpB) Antikörper

Produktnummer ABIN7489927

Der Maus Monoklonal anti-Arginine-Gingipain B (RgpB) Antikörper wird verwendet zum Nachweis von Arginine-Gingipain B (RgpB) in Proben von Porphyromonas gingivalis. Er wurde validiert für IHC und WB.

Kurzübersicht für Arginine-Gingipain B (RgpB) Antikörper (ABIN7489927)

Target: Arginine-Gingipain B (RgpB)

Reaktivität: Porphyromonas gingivalis

Wirt: Maus

Klonalität: Monoklonal

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Klon: 18E6-F7

Produktdetails

Spezifität: This antibody recognizes a unique epitope within the immunoglobulin (Ig)-like domain of arginine-gingipain (RgpB).

Kreuzreaktivität: Porphyromonas gingivalis

Immunogen: Arginine-gingipain B (RgpB) from Porphyromonas gingivalis.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Paraffin-embedded formalin-fixed AD hippocampus and gingival tissue from a patient with periodontal disease stained with #13925 and compared to non-AD control tissue and mouse IgG1 control (see Dominy et al. Science Advances 5 (1): eaau3333).
Detection of RgpB in P. gingivalis wild-type strain W83 whole cells (see Nguyen K-A et al. J Bacteriol 189: 833-843).

Kommentare:

Anti-Gngipaing B (RgpB) Mouse Monoclonal Antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Konzentration: Lot specific

Buffer: PBS, pH 7.4,Phosphate Buffered Saline

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one (1) year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.

Antigendetails

Target: Arginine-Gingipain B (RgpB)

Hintergrund: Gingipain B,Arginine-gingipain B (RgpB) is a cysteine protease produced exclusively by Porphyromonas gingivalis, and it plays a central role in the pathogenicity of P. gingivalis in periodontal disease. Over the last several years, a possible association between Alzheimer disease (AD) and chronic periodontitis has been suggested based on detection of P. gingivalis infiltration in autopsy specimens from the brains of people with AD in association with neurons, tau tangles, and beta-amyloid as well as in cerebrospinal fluid of individuals diagnosed with AD. Oral administration of a gingipain inhibitor to mice with established brain infection by P. gingivalis decreased the amount of P. gingivalis DNA in brain as well as the levels of beta-amyloid and tumor necrosis factor-α. Taken together, the data suggest that gingipain inhibitors might be an effective treatment of AD. Clinical trials of gingipain inhibitors are currently underway.,Arginine-gingipain B

UniProt: Q51844