Rekombinanter FCAR Antikörper

Produktnummer ABIN7487709

Der Maus Monoklonal Anti-FCAR-Antikörper wurde für FACS, ELISA und IP validiert. Er ist geeignet, FCAR in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter FCAR Antikörper (ABIN7487709)

Target: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCAR Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP)

Klon: 14A8

Produktdetails anti-FCAR Antikörper

Verwendungszweck: Anti-CD89 [14A8 (14.1)], Mouse IgG1, kappa

Spezifität: This antibody binds CD89 in the extracellular domain 2, outside the IgA-binding site.

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing HCO12 trangene containing mice with recombinant soluble CD89 antigen.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds human CD89 with a dissociation constant of Kd= 6.8 X10-10M.The binding of this antibody to human CD89 was confirmed with ELISA. This antibody was also capable of recognizing human CD89 expressing cells like human PMNL cells by flow cytometry. This antibody is not capable of blocking binding of IgA to CD89. This antibody can used to immunoprecipitate soluble CD89 (US7192582). A bispecific antibody construct incorporating the variable regions of the anti-gp41 antibody F240 and the anti-CD89 (immunoglobulin A [IgA] receptor) antibody 14A8 was reported to promote destruction of HIV type 1 (HIV-1) by neutrophils (PMID: 18272577). A Fab-like bispecific antibody molecule or Bi-Fab antibody generated from F240scFv and 14A8scFv showed significant antiboy dependent cell-mediated viral inhibition (ADCVI) activity for multiple clade B and clade C isolates by arming the neutrophils to inhibit HIV infection (PMID: 27419146).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu FCAR

Target: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Andere Bezeichnung: CD89

Hintergrund: Immunoglobulin alpha Fc receptor, FCAR, IgA Fc receptor, FcαR

UniProt: P24071