ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1) (C-Term) Antikörper

Produktnummer ABIN7468312

Der Kaninchen Polyklonal anti-ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 Antikörper wird verwendet zum Nachweis von ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1) (C-Term) Antikörper (ABIN7468312)

Target: ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Western Blotting (WB)

Produktdetails

Bindungsspezifität: C-Term

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human EDEM1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Jurkat membrane extract Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.21 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Antigendetails

Target: ER Degradation-Enhancing alpha-Mannosidase-Like Protein 1 (EDEM1)

Andere Bezeichnung: ER degradation enhancing alpha-mannosidase like protein 1

Hintergrund:

Synonyms: ER degradation enhancing alpha-mannosidase like protein 1 , EDEM

Background: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.

Molekulargewicht: 74 kDa

Gen-ID: 9695

UniProt: Q92611