CCM2 Antikörper

Produktnummer ABIN7468108

Der Kaninchen Polyklonal Anti-CCM2-Antikörper wurde für WB validiert. Er ist geeignet, CCM2 in Proben von Human zu detektieren.

Kurzübersicht für CCM2 Antikörper (ABIN7468108)

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CCM2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CCM2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: 293T

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu CCM2

Target: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Andere Bezeichnung: CCM2 scaffold protein

Hintergrund:

Synonyms: CCM2 scaffold protein , C7orf22 , OSM , PP10187

Background: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 49 kDa

Gen-ID: 83605

UniProt: Q9BSQ5

Pathways: Cell-Cell Junction Organization