CRTC1 Antikörper (N-Term)

Produktnummer ABIN7466212

Der Kaninchen Polyklonal Anti-CRTC1-Antikörper wurde für WB validiert. Er ist geeignet, CRTC1 in Proben von Human zu detektieren.

Kurzübersicht für CRTC1 Antikörper (N-Term) (ABIN7466212)

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CRTC1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human TORC1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:5000-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: human CRTC1-transfected 293T

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.9 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: CREB regulated transcription coactivator 1

Hintergrund: CREB regulated transcription coactivator 1 , MAML2 , MECT1 , Mam-2 , TORC-1 , TORC1 , WAMTP1,Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.

Molekulargewicht: 67 kDa

Gen-ID: 23373

UniProt: Q6UUV9