USP20 Antikörper

Produktnummer ABIN7465301

Dieses Anti-USP20-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP20 in WB. Geeignet für Human.

Kurzübersicht für USP20 Antikörper (ABIN7465301)

Target: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-USP20 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Affinity purified by Protein A.

Immunogen: Recombinant protein encompassing a sequence within the center region of human USP20. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: 293T , Raji

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.98 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu USP20

Target: USP20 (Ubiquitin Specific Peptidase 20 (USP20))

Andere Bezeichnung: ubiquitin specific peptidase 20

Hintergrund: Ubiquitin specific peptidase 20 , LSFR3A , VDU2 , hVDU2,Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Molekulargewicht: 102 kDa

Gen-ID: 10868

UniProt: Q9Y2K6

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling