Estrogen Receptor alpha Antikörper (AA 1-190)

Produktnummer ABIN7464705

Dieser Maus Monoklonal Antikörper detektiert spezifisch Estrogen Receptor alpha in WB, FACS, IP und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Estrogen Receptor alpha Antikörper (AA 1-190) (ABIN7464705)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 1F3

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: AA 1-190

Spezifität: This antibody is specific for ER alpha protein, and it does not cross react with ER beta protein.

Kreuzreaktivität: Human, Kaninchen

Aufreinigung: Protein G purified

Immunogen: The region encoding amino acids 1-190 expressed in E. coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IP: 1 - 5 μg/mL. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: MCF-7 , DDDDK-tagged ESR1-transfected 293T

Validation: Comparison, Orthogonal, Overexpression

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.56 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: estrogen receptor 1

Hintergrund: Estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1,This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Molekulargewicht: 66 kDa

Gen-ID: 2099

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly