X-Ray Repair Cross Complementing 5 (C-Term) Antikörper

Produktnummer ABIN7464656

Dieses Anti--Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von in WB, ICC und IF. Geeignet für Human.

Kurzübersicht für X-Ray Repair Cross Complementing 5 (C-Term) Antikörper (ABIN7464656)

Target: X-Ray Repair Cross Complementing 5

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Güteklasse: KO Validated

Klon: 149-8

Produktdetails

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Affe

Aufreinigung: Protein G purified

Immunogen: Recombinant antigen containing the carboxy terminal portion of human Ku80 protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Jurkat , Raji , 293T , A431 , HeLa , HepG2 , H1299 , HCT116 , MCF-7 , NT2D1 , PC-3 , U87-MG

Validation: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Antigendetails

Target: X-Ray Repair Cross Complementing 5

Hintergrund: X-ray repair cross complementing 5 , KARP-1 , KARP1 , KU80 , KUB2 , Ku86 , NFIV,The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Molekulargewicht: 83 kDa

Gen-ID: 7520

UniProt: P13010