NCOR2 Antikörper (AA 994-1005)

Produktnummer ABIN7464419

Dieses Anti-NCOR2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von NCOR2 in WB, IP, IHC (fro) und ChIP. Geeignet für Human.

Kurzübersicht für NCOR2 Antikörper (AA 994-1005) (ABIN7464419)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NCOR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Chromatin Immunoprecipitation (ChIP)

Güteklasse: KO Validated

Klon: 1212

Produktdetails anti-NCOR2 Antikörper

Bindungsspezifität: AA 994-1005

Kreuzreaktivität: Human, Affe

Aufreinigung: Protein G purified

Immunogen: A synthetic peptide from the human SMRT protein corresponding to amino acids 994-1005 (ASASDPHREKTQ) coupled to KLH.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: For ChIP: Use 3 μL for 10^6 cells. For IHC-Fr: Use at a dilution of 1:50. Immunohistochemical staining of SMRT in HeLa cells with this antibody results in nuclear staining. For WB: Use at a dilution of 1:250. Detects a band of approximately 220-250 kDa (predicted molecular weight: 274 kDa). Optimal dilutions/concentration should be determined by the researcher.

Kommentare:

Positive Control: HBL100

Validation: KO/KD

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, No Preservative

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Andere Bezeichnung: nuclear receptor corepressor 2

Hintergrund: Nuclear receptor corepressor 2 , CTG26 , N-CoR2 , SMAP270 , SMRT , SMRTE , SMRTE-tau , TNRC14 , TRAC , TRAC-1 , TRAC1,This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Molekulargewicht: 274 kDa

Gen-ID: 9612

UniProt: Q9Y618

Pathways: Notch Signalweg, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha