Interleukin 17a Antikörper (PE)

Produktnummer ABIN7457103

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Interleukin 17a in ICFC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Interleukin 17a Antikörper (PE) (ABIN7457103)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Interleukin 17a Antikörper ist konjugiert mit PE

Applikation: Intracellular Flow Cytometry (ICFC)

Klon: BL168

Produktdetails anti-Interleukin 17a Antikörper (PE)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Kommentare:

Matching Isotype Control: PE Mouse IgG1, κ Isotype Control (ABIN7469761)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Details zu Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Andere Bezeichnung: IL-17A

Hintergrund: CTLA8, IL17,CTLA-8,IL 17A,IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63 % , 63 %, and 72 % amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.

Gen-ID: 3605

UniProt: Q16552