XPO5 Antikörper (AA 1154-1204)

Produktnummer ABIN7454998

Der Kaninchen Polyklonal Anti-XPO5-Antikörper wurde für WB, IP und IHC (fp) validiert. Er ist geeignet, XPO5 in Proben von Human und Maus zu detektieren.

Kurzübersicht für XPO5 Antikörper (AA 1154-1204) (ABIN7454998)

Target: XPO5 (Exportin 5 (XPO5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPO5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-XPO5 Antikörper

Bindungsspezifität: AA 1154-1204

Verwendungszweck: Rabbit anti-Exportin-5 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 1154 and 1204

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu XPO5

Target: XPO5 (Exportin 5 (XPO5))

Andere Bezeichnung: Exportin-5

Hintergrund: Background: Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exportin-5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport [taken from the Universal Protein Resource (UniProt) Q9HAV4].

Gen-ID: 57510

NCBI Accession: NP_065801

UniProt: Q9HAV4

Pathways: Regulatorische RNA Pathways, Protein targeting to Nucleus